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008			090222s2006 enka |b 001 0 eng
020			_a0195150961 (cloth : alk. paper)
020			_a0195182189 (pbk. : alk. paper)
039		9	_a201402040131 _bVLOAD _c201010020906 _dmalmash _c200902220911 _dvenkatrajand _c200902220910 _dvenkatrajand _y200902220909 _zvenkatrajand
050	0	0	_aQH324.9.T45 _bF73 2006
082	0	0	_a570/.28/25 _222
100	1		_aFrank, J. _q(Joachim), _d1940- _911278
245	1	0	_aThree-dimensional electron microscopy of macromolecular assemblies : _bvisualization of biological molecules in their native state / _cJoachim Frank.
250			_a2nd ed.
260			_aOxford ; _aNew York : _bOxford University Press, _c2006.
300			_axiv, 410 p. : _bill. ; _c25 cm.
504			_aIncludes bibliographical references (p. 345-398) and index.
520			_aCryoelectron microscopy of biological molecules is among the hottest growth areas in biophysics and structural biology at present, and Frank is arguably the most distinguished practitioner of this art. CryoEM is likely over the next few years to take over much of the structural approaches currently requiring X-ray crystallography, because one can now get good and finely detailed images of single molecules down to as little as 200,000 MW, covering a substantial share of the molecules of greatest biomedical research interest. This book, the successor to an earlier work published in 1996 with Academic Press, is a natural companion work to our forthcoming book on electron crystallography by Robert Glaeser, with contributions by six others, including Frank. A growing number of workers will employ CryoEM for structural studies in their own research, and a large proportion of biomedical researchers will have a growing interest in understanding what the capabilities and limits of this approach are.
650		0	_aThree-dimensional imaging in biology. _911279
650		0	_aElectron microscopy. _911280
856	4		_3Table of contents only _uhttp://www.loc.gov/catdir/toc/ecip0421/2004018762.html
856	4		_3Publisher description _uhttp://www.loc.gov/catdir/enhancements/fy0640/2004018762-d.html
856	4		_3Contributor biographical information _uhttp://www.loc.gov/catdir/enhancements/fy0722/2004018762-b.html
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