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008 081220m2007 enka |b 001 0 eng
020 _a0195300815 (v. 1 : alk. paper)
020 _a9780195300819 (v. 1 : alk. paper)
020 _a0195300807 (v. 2 : alk. paper)
020 _a9780195300802 (v. 2 : alk. paper)
039 9 _a201402040114
_bVLOAD
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_dmalmash
_c201009191010
_dmalmash
_c200812201345
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_y200812200908
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042 _apcc
050 0 0 _aQH324.2
_b.S97 2007
060 1 0 _aQU 58.5
_bS995 2006
245 0 0 _aSystems Biology /
_cedited by Isidore Rigoutsos & Gregory Stephanopoulos.
260 _aOxford ;
_aNew York :
_bOxford University Press,
_cc2007.
300 _a2 v. :
_bill. ;
_c25 cm.
440 0 _aSeries in systems biology
_925427
504 _aIncludes bibliographical references and index.
505 _a1. Mass Spectrometry in Systems Biology 3; 2. Mathematical Modeling and Optimization Methods for De Novo Protein Design 42; 3. Molecular Simulation and Systems Biology 67; 4. Global Gene Expression Assays: Quantitative Noise Analysis 103; 5. Mapping the Genotype-Phenotype Relationship in Cellular Signaling Networks: Building Bridges Over the Unknown 137; 6. Integrating Innate Immunity into a Global Systems Context: The Complement Paradigm Shift 169; 7. Systems Biotechnology: Combined in Silico and Omics Analyses for the Improvement of Microorganisms for Industrial Applications 193; 8. Genome-Scale Models of Metabolic and Regulatory Networks 232; 9. Biophysical Models of the Cardiovascular System 265; 10. Embryonic Stem Cells as a Module for Systems Biology 297; Index 319
520 _aFamiliar sciences of biology, physics, chemistry, cybernetics, and computational methods for dealing with vast new data sets of information at molecular and sub-molecular levels are morphing into new sciences. Some exist beneath our line of sight where laws of nature hover between Newtonian and quantum mechanics. New fields of cyber-, bio-, nanotechnology and systems biology raise arcane new concepts. The completed human genome has led to an explosion of interest in genetics and molecular biology. The view of the genome as a network of interacting computational components is well established and here writers explore it in new ways. These systemic approaches are timely in light of the availability of an increasing number of genomic sequences, and the generation of large volumes of biological data by high-throughput methods. Suitable for two-semesters of study, the works surveys genomics principles in the 13 chapters of Vol I, and networks and models in the 14 chapters of Vol II. Both, as a two-book set, will serve as core foundation titles for Dennis Shasha's Series in Systems Biology, establishing the principles and challenges for this emerging field of study. In each chapter world-renowned experts trail-blazing in their respective fields will review corresponding topics as well as current and planned research. Chapters will treat the integrated study and analysis of biological systems by use of data and information about the system components in their entirety, as opposed to the study of individual components in isolation. Systems Biology courses are popping up all over the place and biology, computer science, and bioinformatics programs are the primary potential takers. The editors plan books for a very wide audience, at the same time providing a comprehensive repository of up-to-date overviews and predictions for a number of inter-related sub-fields within this hierarchy. Intended readers include graduate students plus academic and professional researchers
650 0 _aSystems biology.
_925428
650 0 _aComputational biology.
_925429
650 0 _aGenomics.
_925430
650 0 _aBioinformatics.
_925431
650 1 2 _aGenomics.
_925430
650 2 2 _aComputational Biology.
_925432
650 2 2 _aModels, Genetic.
_925433
650 2 2 _aSystems Biology.
_925434
942 _2lcc
_n0
_cBK
999 _c10522
_d10522