NMR Spectroscopy of Glycoconjugates /
edited by J. Jiménez-Barbero and T. Peters.
- Weinheim : Wiley-VCH, c2003.
- xv, 320 p. : ill. ; 25 cm.
Includes bibliographical references and index.
Preface.Abbreviations.PART A: PARAMETERS, TECHNIQUES AND EXPERIMENTS.Relaxation and Dynamics (G. Widmalm).Residual Dipolar Couplings in Bacterial Polysaccharides (M. Martin-Pastor & C. Bush).Detection of Hydroxyl Protons (H. Siebert, et al.).NMR of Carbohydrates: 1D Homonuclear Selective Methods (J. Brisson, et al.).NMR Experiments for Large Carbohydrates (S. Vincent).PART B: STRUCTURAL AND CONFORMATIONAL ANALYSIS OF CARBOHYDRATE MOLECULES BY NMR.Combining NMR and Simulation Methods in Oligosaccharide Conformational Analysis (T. Weimar & R. Woods).The Unique Solution Structure and Immunochemistry of the Candida albicans s1,2-Mannopyranan Cell Wall Antigen (M. Nitz & D. Bundle).NMR of Sulfated Oligo- and Polysaccharides (M. Hricovini, et al.).Residual Dipolar Couplings: Structure and Dynamics of Glycolipids (J. Prestegard & J. Glushka).Activated Sugars (C. Monteiro & C. Herve du Penhoat).PART C: INTERACTIONS OF CARBOHYDRATES WITH BIOMOLECULES INVESTIGATED BY NMR TECHNIQUES AND APPLICATIONS.NMR Analysis of Carbohydrate - Carbohydrate Interactions (A. Geyer).TR-NOE Experiments to Study Carbohydrate-Protein Interactions (J. Jimenez-Barbero & T. Peters).Subject Index.
While for many years NMR spectroscopy was one of the most useful methods of analyzing smaller molecules, nowadays, it is an indispensable tool in determining the structure of complex biomolecules too. One reason for this is not least the development of increasingly powerful appliances that enabled this complicated analysis using tiny amounts of the substances in the first place. Just as the image of a 2D spectrum allows an insight into the spatial structure of a molecule, the chronological examination of an NMR experiment enables the description of the molecular dynamics. It is only by explaining such characteristics that we can really come to understand the functioning of biomolecules. This book is neither a purely analytical nor bioorganic work, and as such fills a gap for everybody working in determining the structure of carbohydrates and their conjugates. In a clearly comprehensible manner, the text summarizes the latest knowledge surrounding the use of NMR spectroscopy with such biologically important substance classes as polysaccharides, glycoproteins and glycolipides. Furthermore, it provides an insight into the interactions with other biomolecules such as proteins, nucleic acids or carbohydrates. This is a valuable guide for all glucochemists.
3527304142 (acidfree paper)
Glycoconjugates--Analysis. Glycoconjugates--Structure. Nuclear magnetic resonance spectroscopy.