MARC details
| 000 -LEADER |
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| fixed length control field |
04141cam a22003014u 4500 |
| 001 - CONTROL NUMBER |
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| control field |
vtls000003291 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
VRT |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250102223204.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
081221s2003 gw a |b 001 0 eng |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
3527304657 (alk. paper) |
| 039 #9 - LEVEL OF BIBLIOGRAPHIC CONTROL AND CODING DETAIL [OBSOLETE] |
|---|
| Level of rules in bibliographic description |
201308051227 |
| Level of effort used to assign nonsubject heading access points |
malmash |
| Level of effort used to assign subject headings |
201308051128 |
| Level of effort used to assign classification |
malmash |
| Level of effort used to assign subject headings |
201006291232 |
| Level of effort used to assign classification |
malmash |
| Level of effort used to assign subject headings |
200812230839 |
| Level of effort used to assign classification |
venkatrajand |
| -- |
200812210901 |
| -- |
Noora |
| 050 00 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RS403 |
| Item number |
.B54 2003 |
| 245 00 - TITLE STATEMENT |
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| Title |
BioNMR in Drug Research / |
| Statement of responsibility, etc. |
edited by Oliver Zerbe. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Weinheim : |
| Name of publisher, distributor, etc. |
Wiley-VCH, |
| Date of publication, distribution, etc. |
c2003. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xxviii, 484 p. : |
| Other physical details |
ill. |
| 440 #0 - SERIES STATEMENT/ADDED ENTRY--TITLE |
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| Title |
Methods and principles in medicinal chemistry ; |
| Volume/sequential designation |
v. 16 |
| 9 (RLIN) |
18492 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographical references and index. |
| 505 ## - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Preface.Foreword.List of Authors.List of Abbreviations.PART I: BASIC TECHNIQUES.Modern Methods for the Expression of Proteins in Isotopically Enriched Form (H. Patzelt, et al.).Structure Calculation Using Automated Techniques (P. Guntert).Achieving Better Sensitivity, Less Noise and Fewer Artifacts in NMR Spectra (D. Moskau & O. Zerbe).PART II: NMR OF BIOMOLECULES.NMR Strategies for Protein Assignments (V. Dotsch).NMR of Membrane-Associated Peptides and Proteins (R. Bader, et al.).NMR of Nucleic Acids (R. Fiala & V. Sklenar). PART III MODERN SPECTROSCOPIC TECHNIQUES.Methods for the Measurement of Angle Restraints from Scalar, Dipolar Couplings from Cross-Correlated Relaxation: Application to Biomacromolecules (C. Griesinger).Orientational Restraints (E. de Alba & N. Tjandra).Scalar Coupling Across Hydrogen Bonds (A. Dingley, et al.).TROSY: Transverse Relaxation-Optimized Spectroscopy (R. Riek).MAS Solid-State NMR of Isotopically Enriched Biological Samples (P. Williamson , et al.).Determination of Protein Dynamics Using 15N Relaxation Measurements (D. Fushman). PART IV: TOOLS FOR INVESTIGATION OF DRUG - RECEPTOR COMPLEXES AND FOR LIGAND SCREENING.The Determination of Equilibrium Dissociation Constants of Protein-Ligand Complexes by NMR (G. Roberts).Experiments in NMR-Based Screening (C. Marchioro, et al.).The Use of Spin Labels in NMR-Supported Lead Finding and Optimization (W. Jahnke).NMR of Weakly Binding Ligands (M. Blommers & S. Rudisser).Isotope Filter and Editing Techniques (G. Gemmecker). PART V: STRATEGIES FOR DRUG DEVELOPMENT USING NMR.Strategies for NMR Screening and Library Design (C. Lepre).Strategies for Hit Finding Using NMR (W. Klaus & H. Senn).Strategies for Drug Discovery Using NMR (M. Blommers, et al.).NMR-Based Drug Design: Approaches for Very Large Proteins (M. Pellecchia, et al.).Subject Index. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wuthrich. Edited by a former coworker of Wuthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids. BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies. With its successful mixture of basic information and application strategies, coupled with many real life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Pharmaceutical chemistry. |
| 9 (RLIN) |
18493 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Nuclear magnetic resonance spectroscopy. |
| 9 (RLIN) |
18494 |
| 650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Drug Design. |
| 9 (RLIN) |
18495 |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Chemistry, Pharmaceutical |
| General subdivision |
methods. |
| 9 (RLIN) |
18496 |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Magnetic Resonance Spectroscopy |
| General subdivision |
methods. |
| 9 (RLIN) |
18497 |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Nuclear Magnetic Resonance, Biomolecular |
| General subdivision |
methods. |
| 9 (RLIN) |
18498 |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Protein Conformation. |
| 9 (RLIN) |
18499 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Library of Congress Classification |
| Suppress in OPAC |
No |
| Koha item type |
Books |
